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Treatment Options

Medications, therapy, and self-help approaches for RSD

Medical Disclaimer

This information is for educational purposes only and should not replace professional medical advice. Always consult with a qualified healthcare provider before starting or changing any treatment.

Medication Overview

While there's no medication specifically approved for RSD, several types may help reduce emotional reactivity:

Alpha-2 Agonists

Examples: Guanfacine (Intuniv), Clonidine (Kapvay)

May help reduce emotional reactivity. About 30% find significant relief.

Stimulants

Examples: Methylphenidate, Amphetamines

Can help with overall emotional regulation by treating underlying ADHD.

MAOIs

Examples: Tranylcypromine (Parnate)

Historical treatment of choice but rarely used due to dietary restrictions.

What Actually Helps

  • Understanding: Simply knowing RSD is neurological, not a character flaw, is profoundly validating
  • Self-awareness: Recognising your triggers and patterns helps you prepare and respond
  • Support system: Having people who understand and can offer reassurance without judgement
  • Skills training: DBT skills, grounding techniques, and cognitive restructuring

In-Depth Guides

Medication Options for RSD

What we know about medications that may help with rejection sensitivity.

10 min read

Therapy Approaches

CBT, DBT, ACT, and other therapeutic approaches for managing RSD.

12 min read

Finding an RSD-Informed Professional

How to find therapists and doctors who understand rejection sensitivity.

7 min read

Self-Help Strategies That Work

Evidence-based techniques you can start using today.

8 min read

Start with understanding your patterns

Our assessment helps you identify your specific RSD patterns, which is the first step toward effective management.

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